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M.Sc. Ali Mansuri

M.Sc. Ali Mansuri Photo of M.Sc. Ali Mansuri

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(+49)231 755-3962

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Room G3-4.16

Contents

Abstract

Amorphous Solid Dispersions (ASDs) are molecular dispersions of an active ingredient (AI) in a polymer carrier, gaining in importance in the life science industry. Nevertheless, ensuring the physical stability of ASD formulations is still challenging as the AI tends to phase separation and crystallises subsequently. This study focuses on determining diffusion coefficients of active ingredients in amorphous polymers as an underlying parameter for the kinetic stability of ASDs.

Description

During the last decades, significant steps have been taken in combating the spread of malaria. Long-lasting insecticide-treated nets as well as indoor residual sprays are two important techniques for controlling malaria. With the growing resistance of malaria vectors against commonly used insecticides, the need for the development and application of new classes of insecticides is increasing.
However, newly developed insecticides pose challenges in terms of strong efficacy variations with respect to their solid state.

Molecularly dispersing the active ingredient in a polymer carrier is one approach to address the efficacy issue. Within the scope of this study, deeper insights into molecular phenomena in polymeric systems containing active ingredients are gained, including phase behaviour and diffusion.

This research project is a cooperation of INVITE GmbH in Leverkusen and TU Dortmund.

research_topic_Ali

Fig. Left: scheme of hopping mechanism for diffusion in polymer matrices. Right: available free volume for diffusion in glassy state [Duda, 2011]

Curriculum VitaE

Since 2019 PhD Candidate at the Laboratory of Solids Process Engineering, TU Dortmund
2015-2018

M.Sc. Chemical and Biological Engineering, University of Erlangen-Nuremberg

Master thesis: Predictability of Dissolution Behaviour in Spray Dried Amorphous Solid Dispersions by a Screening Method

2008-2014

B.Sc. Chemical Engineering, Ferdowsi University of Mashhad

Bachelor thesis: Feasibility Study of a Biodiesel Production Plant: A Comparison Between Different Catalytic Concepts under the effect of THF as cosolvent

2004-2008 Sama High School (Mashhad)
Born November 17th, Mashhad (Iran)

Sub content

Cooperation

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